Nursing research summary

Nursing Practice for Patients with Cancer Pain with Predicted Prognosis of Months or Weeks: A Multicenter Cross-Sectional Study in Japan

A Japanese nationwide survey of 539 palliative care unit nurses found that basic comfort care and repositioning were frequently used for cancer pain (about 80% of nurses), regardless of whether a patient's prognosis was months or weeks, while specialized nonpharmacological therapies like guided imagery and reflexology were used by fewer than 20%.

Palliative Medicine Reports Published 2025 3 min read DOI 10.1089/pmr.2024.0103

In brief

A Japanese nationwide survey of 539 palliative care unit nurses found that basic comfort care and repositioning were frequently used for cancer pain (about 80% of nurses), regardless of whether a patient's prognosis was months or weeks, while specialized nonpharmacological therapies like guided imagery and...

What this article is about

Quick Answer

A Japanese nationwide survey of 539 palliative care unit nurses found that basic comfort care and repositioning were frequently used for cancer pain (about 80% of nurses), regardless of whether a patient's prognosis was months or weeks, while specialized nonpharmacological therapies like guided imagery and reflexology were used by fewer than 20%.

Student takeaways

Key Takeaways

  • Researchers surveyed nurses from 162 of 389 invited Japanese palliative care units nationwide, with 539 of 2,448 invited nurses responding (22.3%).
  • Implementation frequencies for the 23 nursing support items assessed were almost the same for patients with a prognosis anticipated in the scale of weeks versus months.
  • Approximately 80% of nurses frequently provided comfort care (environmental adjustment, mental health care, oral care) and adjusted patient postures and positions for cancer pain.
  • Fewer than 20% of nurses frequently implemented more specialized nonpharmacological therapies, including progressive muscle relaxation, guided imagery therapy, cognitive behavioral intervention, reflexology, and reiki.
  • The study relied on descriptive statistics of implementation frequency rather than statistical significance testing, reflecting its exploratory, practice-mapping design.

Student summary

Why This Research Matters

Cancer pain does not always need a pill or an injection to be eased. Nurses working in palliative care units (PCUs) also use nonpharmacological, hands-on comfort measures — things like adjusting a patient's position, keeping the room calm, or offering mouth care — alongside medication. Until now, though, nobody had a clear national picture of how often Japanese PCU nurses actually use these approaches, or whether that changes as a patient's expected survival time shortens from months to weeks. This study, published in Palliative Medicine Reports in 2025 by Morikawa, Kobayashi, Kajiwara, Nakano, Kanno, Matsuda, and Kako, set out to answer that question.

The researchers ran a nationwide online survey of registered nurses working in Japanese PCUs. They contacted all 389 PCUs operating in Japan and asked them to take part; 162 units agreed. Individual nurses at those units were then invited to respond anonymously, and 539 of the 2,448 nurses invited completed the survey — a response rate of 22.3%. Nurses were asked how often they carried out each of 23 defined nursing support items for cancer pain, separately for patients whose prognosis was estimated in months and for those whose prognosis was estimated in weeks. Rather than running statistical significance tests, the team reported descriptive statistics — essentially, how common each practice was, expressed as a percentage of nurses using it frequently.

The headline finding was that the pattern of care barely changed between the "months" group and the "weeks" group: nurses used roughly the same mix of supports regardless of how close to end of life the patient was thought to be. What did vary a lot was which types of support were common at all. About 80% of nurses said they frequently provided what the study calls "comfort care" — adjusting the room environment, offering emotional/mental health support, and doing oral care — plus repositioning the patient to ease pain. These are relatively simple, low-tech measures that most bedside nurses can do without extra equipment or specialized training.

On the other end of the spectrum, a long list of more specialized nonpharmacological therapies were used frequently by fewer than 20% of nurses. These included progressive muscle relaxation, guided imagery, combined relaxation techniques, cognitive behavioral interventions, reflexology, self-administered acupressure, therapeutic exercise, poetry appreciation, auricular acupressure, virtual-reality-based relaxation, and reiki. In other words, the techniques that usually require dedicated training, certification, or specialized equipment were rarely used, even though there is a body of evidence supporting some of them for pain and distress.

The authors concluded that basic comfort care and positioning are the backbone of everyday nonpharmacological pain support in Japanese PCUs, while more specialized techniques remain underused. They frame this as an opportunity: expanding nurses' access to training, time, and resources for these underused therapies could broaden the toolkit available for patients with cancer pain near the end of life.

For a nursing student, the practical takeaway is twofold. First, comfort measures that feel almost too simple — repositioning a patient, adjusting lighting or noise, doing mouth care, sitting with someone who is anxious — are exactly the kind of evidence-informed, low-barrier interventions that frontline nurses rely on constantly, and they deserve to be taken seriously as clinical skill, not just "basic care." Second, the gap between what is recommended in palliative care literature and what is actually implemented at the bedside is real and worth questioning: if a technique like guided imagery or reflexology is rarely used, is that because it doesn't work, because nurses lack training, because units lack time or staff, or because there's no clear protocol for offering it? This study cannot tell us which explanation is correct — it only tells us the practice gap exists. As with any single cross-sectional survey from one country, be cautious about assuming these percentages would look the same in a Canadian or other international PCU, and remember that self-reported frequency of care is not the same as verified clinical practice.

Source abstract

Study Overview

Background: Nonpharmacological therapies implemented by nurses in clinical practice for patients with cancer pain remain unclear. Objective: To investigate nursing support for patients with cancer pain in Japanese palliative care units (PCUs). Design: Nationwide online survey. Setting/Subjects: Registered nurses in Japanese PCUs. Measurements: Herein, we conducted a questionnaire survey to assess the frequency of care implementation for 23 nursing support items for patients with cancer pain with prognoses anticipated in the scale of weeks or months, asking nurses working in PCUs to respond anonymously. We did not perform statistical tests on the results, instead of calculating descriptive statistics on implementation frequencies. Results: We requested surveys from 389 PCUs nationwide and 162 participated. Of 2,448 invited nurses, 539 (22.3%) responded. The implementation frequencies for the 23 nursing support items were almost the same for patients with prognosis anticipated in the scale of weeks or months. Approximately 80% frequently provide comfort care (environmental adjustment/mental health care/oral care) and adjust postures and positions. Conversely, support options frequently implemented by <20% of the participants included progressive muscle relaxation therapy, guided imagery therapy, combined therapy, cognitive behavioral intervention, reflexology, self-administered acupressure, exercise, poetry appreciation, auricular acupressure, relaxation using virtual reality, and reiki. Conclusion: Our findings indicate that comfort care and positioning adjustments are frequently provided for patients with cancer with prognosis anticipated in the scale of weeks or months to improve well-being. Nursing support practices requiring specialized skills were less frequently implemented. These results offer insights for expanding palliative care support options.

Study type: Open access journal article

Evidence appraisal

Main Findings

  • Researchers surveyed nurses from 162 of 389 invited Japanese palliative care units nationwide, with 539 of 2,448 invited nurses responding (22.3%).
  • Implementation frequencies for the 23 nursing support items assessed were almost the same for patients with a prognosis anticipated in the scale of weeks versus months.
  • Approximately 80% of nurses frequently provided comfort care (environmental adjustment, mental health care, oral care) and adjusted patient postures and positions for cancer pain.
  • Fewer than 20% of nurses frequently implemented more specialized nonpharmacological therapies, including progressive muscle relaxation, guided imagery therapy, cognitive behavioral intervention, reflexology, and reiki.
  • The study relied on descriptive statistics of implementation frequency rather than statistical significance testing, reflecting its exploratory, practice-mapping design.

Practice transfer

Clinical Relevance

  • Basic comfort measures — environmental adjustment, emotional support, oral care, and repositioning — appear to be the most consistently delivered nonpharmacological pain supports and warrant continued emphasis as core bedside skills, not an afterthought to pharmacologic pain control.
  • The low reported use of specialized nonpharmacological therapies (e.g., guided imagery, progressive muscle relaxation, acupressure) suggests a potential gap between recommended complementary approaches and what is feasible in everyday PCU practice; units may want to assess training and time barriers before assuming lack of interest.
  • Because implementation did not differ meaningfully between patients with months-scale versus weeks-scale prognoses, nurses and teams should consciously reassess whether comfort-focused nonpharmacological care is being adequately intensified or individualized as death approaches, rather than assuming current practice already adapts.
  • Findings should be used to prompt local discussion about which specialized therapies (e.g., reflexology, guided imagery) could be integrated with additional training or interdisciplinary support, rather than as proof that these therapies are ineffective.
  • As a self-reported, Japan-specific survey, findings should inform reflection and local quality-improvement discussions rather than be applied directly as a practice standard in Canadian settings without further local assessment.

Faculty notes

Educational Relevance

This 2025 Palliative Medicine Reports article by Morikawa, Kobayashi, Kajiwara, Nakano, Kanno, Matsuda, and Kako reports a nationwide, multicenter cross-sectional survey describing how often Japanese palliative care unit (PCU) nurses implement 23 defined nonpharmacological nursing support items for cancer pain, and whether implementation frequency differs by patient prognosis category (months vs. weeks). The team invited all 389 PCUs operating nationally; 162 facilities agreed to participate, and nurses at those units were invited anonymously online, yielding 539 respondents from 2,448 invited nurses (22.3% individual response rate). No inferential statistical testing was performed; findings are reported as descriptive implementation frequencies, which is an appropriate and transparent choice given the study's exploratory, mapping purpose but limits any claim of a statistically meaningful difference between the two prognosis groups.

The central finding for classroom discussion is the near-identical implementation pattern across the two prognosis strata — nurses did not appear to meaningfully change their nonpharmacological pain-support repertoire as patients moved from a months-scale to a weeks-scale prognosis. A clear implementation hierarchy also emerged: general comfort measures (environmental adjustment, mental/emotional support, oral care) and positioning/posture adjustment were frequently used by roughly 80% of respondents, while an extensive set of more specialized nonpharmacological therapies — progressive muscle relaxation, guided imagery, combined therapy, cognitive-behavioral intervention, reflexology, self-administered acupressure, exercise, poetry appreciation, auricular acupressure, virtual-reality relaxation, and reiki — were frequently used by fewer than 20% of nurses each.

For appraisal purposes, this is a hypothesis-generating descriptive survey, not an intervention or outcomes study: it tells us what nurses report doing, not whether any given practice improves pain control, and it cannot establish why specialized therapies are underused (training gaps, time/staffing constraints, lack of institutional protocols, or absence of perceived efficacy are all plausible and indistinguishable here). The 22.3% individual response rate and 41.6% facility participation rate (162/389) raise nonresponse bias concerns — nurses more interested in or confident about nonpharmacological pain care may have been more likely to respond. All data are self-reported frequency estimates rather than observed practice, and the sample is drawn exclusively from Japanese PCUs, which limits direct generalizability to Canadian or other international palliative settings given differences in staffing models, scope of practice, and training infrastructure for complementary therapies.

Methodologically, this paper belongs to a coordinated research program by the same author group examining nonpharmacological nursing support across several cancer symptoms (pain, nausea/vomiting, dyspnea, delirium) using the same national PCU sampling frame; a companion nausea/vomiting paper from the same project, drawing on the identical 389-PCU/162-participating, 2,448-invited/539-responding sampling frame (used here only as supplementary methodological context, not as evidence for this paper's own results), reports the survey was conducted online from October 2023 to March 2024 using a five-point Likert implementation-frequency scale. Instructors can use this article to teach critical appraisal of descriptive cross-sectional surveys: discuss why no statistical testing was used, what response-rate transparency adds to trustworthiness, and how a practice-frequency gap (common comfort care vs. rare specialized therapy) should inform — but not dictate — curriculum and continuing-education priorities in palliative and oncology nursing.

Critical appraisal

Limitations

  • The individual nurse response rate was only 22.3% (539 of 2,448 invited), and facility participation was 41.6% (162 of 389 PCUs), raising the possibility of nonresponse bias toward nurses more engaged with nonpharmacological pain care.
  • All implementation data were self-reported by nurses rather than directly observed, so reported frequencies may not precisely reflect actual clinical practice.
  • The cross-sectional, single-country (Japan) design limits generalizability to nursing practice in other health systems, including Canada, where staffing models, scope of practice, and complementary-therapy training differ.

Classroom use

Discussion Questions

  • Why might implementation frequency for nonpharmacological pain support look nearly identical between patients with a months-scale versus a weeks-scale prognosis, and is that a desirable finding or a cause for concern?
  • What barriers might explain why specialized therapies like guided imagery, reflexology, or progressive muscle relaxation were used by fewer than 20% of nurses, despite evidence supporting some of these approaches?
  • How would you distinguish, in your own clinical setting, whether low use of a specialized comfort therapy reflects lack of training, lack of time, lack of protocol, or lack of perceived benefit?
  • What are the strengths and weaknesses of relying on descriptive statistics rather than inferential statistical tests in a survey like this one?
  • How might a 22.3% response rate affect how confidently we can generalize these findings to all Japanese PCU nurses, let alone nurses elsewhere?
  • In what ways could 'comfort care' (environmental adjustment, mental health care, oral care) be considered a specialized nursing skill rather than a baseline expectation?
  • If you worked in a Canadian palliative care unit, what factors would you expect to differ from this Japanese sample in terms of nonpharmacological pain support availability?
  • What would a follow-up study need to include to explain why implementation of specialized therapies is low — for example, training records, staffing ratios, or patient preference data?
  • How should findings from a single national self-report survey influence continuing education priorities for oncology and palliative care nurses?
  • What ethical considerations arise when patients near end of life have unequal access to specialized nonpharmacological pain therapies depending on which unit or nurse is assigned to their care?

Knowledge check

Quiz

1. What was the primary objective of this study?

  1. To compare opioid dosing strategies across Japanese hospitals
  2. To investigate nursing support for patients with cancer pain in Japanese palliative care units
  3. To test a new pain assessment tool in oncology wards
  4. To evaluate patient satisfaction with pain medication
Answer: To investigate nursing support for patients with cancer pain in Japanese palliative care units
Rationale: The abstract states the objective was 'to investigate nursing support for patients with cancer pain in Japanese palliative care units (PCUs).'

2. How many nursing support items for cancer pain were assessed in the questionnaire?

  1. 13
  2. 18
  3. 23
  4. 30
Answer: 23
Rationale: The abstract states the survey assessed 'the frequency of care implementation for 23 nursing support items for patients with cancer pain.'

3. What was the individual nurse response rate in this survey?

  1. 10.5%
  2. 22.3%
  3. 41.6%
  4. 55.0%
Answer: 22.3%
Rationale: The abstract states 'Of 2,448 invited nurses, 539 (22.3%) responded.'

4. How did implementation frequencies for the 23 nursing support items compare between patients with prognoses of weeks versus months?

  1. Frequencies were almost the same for both prognosis groups
  2. Weeks-prognosis patients received far more specialized therapies
  3. Months-prognosis patients received almost no comfort care
  4. The study found statistically significant differences between the groups
Answer: Frequencies were almost the same for both prognosis groups
Rationale: The abstract states 'The implementation frequencies for the 23 nursing support items were almost the same for patients with prognosis anticipated in the scale of weeks or months.'

5. Approximately what percentage of nurses frequently provided comfort care (environmental adjustment/mental health care/oral care) and postural adjustments?

  1. 20%
  2. 50%
  3. 80%
  4. 100%
Answer: 80%
Rationale: The abstract states 'Approximately 80% frequently provide comfort care (environmental adjustment/mental health care/oral care) and adjust postures and positions.'

6. Which of the following was frequently implemented by fewer than 20% of participating nurses, according to the abstract?

  1. Oral care
  2. Environmental adjustment
  3. Guided imagery therapy
  4. Postural adjustment
Answer: Guided imagery therapy
Rationale: The abstract lists guided imagery therapy among support options 'frequently implemented by <20% of the participants.'

7. How many palliative care units (PCUs) were requested to participate, and how many actually took part?

  1. 162 requested, 389 participated
  2. 389 requested, 162 participated
  3. 2,448 requested, 539 participated
  4. 539 requested, 162 participated
Answer: 389 requested, 162 participated
Rationale: The abstract states 'We requested surveys from 389 PCUs nationwide and 162 participated.'

8. What statistical approach did the researchers use to analyze the survey results?

  1. Multivariate regression analysis
  2. Descriptive statistics on implementation frequencies, without statistical significance testing
  3. A randomized controlled trial design
  4. Qualitative thematic analysis only
Answer: Descriptive statistics on implementation frequencies, without statistical significance testing
Rationale: The abstract states 'We did not perform statistical tests on the results, instead of calculating descriptive statistics on implementation frequencies.'

9. According to the study's conclusion, what type of nursing support was less frequently implemented?

  1. Comfort care and positioning adjustments
  2. Nursing support practices requiring specialized skills
  3. Basic vital sign monitoring
  4. Medication administration
Answer: Nursing support practices requiring specialized skills
Rationale: The abstract concludes 'Nursing support practices requiring specialized skills were less frequently implemented.'

10. What is a key limitation of this study's design that affects how confidently the findings can be generalized?

  1. It was conducted as a randomized controlled trial with a placebo group
  2. It is a single-country, cross-sectional, self-reported survey with a 22.3% individual response rate
  3. It only surveyed physicians, not nurses
  4. It excluded all patients with a prognosis of weeks
Answer: It is a single-country, cross-sectional, self-reported survey with a 22.3% individual response rate
Rationale: The abstract describes a nationwide online cross-sectional survey of Japanese PCU nurses with a 22.3% response rate (539 of 2,448 invited), a design that inherently limits generalizability and reflects self-report rather than observed practice.

Study cards

Flashcards

What type of study design was used in this research?

A nationwide, multicenter, cross-sectional online survey of registered nurses in Japanese palliative care units (PCUs).

How many nursing support items for cancer pain did the survey assess?

23 nursing support items.

How many PCUs were invited to participate, and how many took part?

389 PCUs nationwide were invited; 162 participated.

How many nurses were invited, and how many responded?

2,448 nurses were invited; 539 responded, a 22.3% response rate.

Did implementation frequency of nursing support items differ between patients with a months-scale versus weeks-scale prognosis?

No, the implementation frequencies were almost the same for both prognosis groups.

What percentage of nurses frequently provided comfort care and postural adjustments?

Approximately 80%.

What three elements make up the 'comfort care' category in this study?

Environmental adjustment, mental health care, and oral care.

Name three specialized nonpharmacological therapies used by fewer than 20% of nurses.

Examples include progressive muscle relaxation, guided imagery therapy, and reflexology (also cognitive behavioral intervention, acupressure, reiki, and others).

Was virtual reality-based relaxation frequently used by nurses in this study?

No, relaxation using virtual reality was among the therapies implemented by fewer than 20% of participants.

What statistical method did the researchers use to analyze implementation frequencies?

Descriptive statistics; no statistical significance testing was performed.

What is the main conclusion of this study regarding comfort care versus specialized therapies?

Comfort care and positioning adjustments were frequently provided, while nursing support practices requiring specialized skills were less frequently implemented.

In what journal and year was this study published?

Palliative Medicine Reports, 2025.

Who are the authors of this study?

Miharu Morikawa, Masamitsu Kobayashi, Kohei Kajiwara, Kimiko Nakano, Yusuke Kanno, Yoshinobu Matsuda, and Jun Kako.

What is the DOI of this article?

10.1089/pmr.2024.0103.

What population was surveyed in this study?

Registered nurses working in Japanese palliative care units.

Why might a 22.3% response rate be considered a limitation?

It raises the possibility of nonresponse bias, since responding nurses may differ systematically from non-responders in their interest in or confidence about pain-related nursing care.

What does 'prognosis anticipated in the scale of weeks or months' refer to in this study?

The estimated remaining survival time of patients with cancer, stratified into two categories used to compare nursing support implementation.

What is one practical implication of this study for palliative care unit staffing or training?

Units may consider assessing training, time, and resource barriers that limit implementation of specialized nonpharmacological pain therapies.

Why is it important to know that no statistical significance testing was performed in this study?

It means observed similarities or differences in implementation frequency between groups cannot be interpreted as statistically confirmed effects, only as descriptive patterns.

What broader research program does this study belong to?

It is part of a coordinated series of studies by the same research group examining nonpharmacological nursing support for multiple cancer symptoms (pain, nausea/vomiting, dyspnea, delirium) using the same national Japanese PCU survey.

Search-ready answers

Frequently asked questions

What did this study find about cancer pain care in Japanese palliative care units?

It found that nurses frequently used basic comfort care (environmental adjustment, mental health care, oral care) and postural adjustments (about 80% of nurses), while more specialized nonpharmacological therapies like guided imagery or reflexology were used by fewer than 20% of nurses.

Did nurses change their approach to pain support as a patient's prognosis got shorter?

No. The study found implementation frequencies for the 23 assessed nursing support items were almost the same whether a patient's prognosis was estimated in months or in weeks.

How many nurses and palliative care units took part in this survey?

Of 389 invited PCUs nationwide in Japan, 162 participated; of 2,448 invited nurses, 539 responded, a 22.3% response rate.

What are the main limitations of this study?

It is a single-country, self-reported, cross-sectional survey with a modest 22.3% response rate and no statistical significance testing, which limits generalizability and the strength of any comparative claims.

Which specialized nonpharmacological pain therapies were least used by nurses in this study?

Progressive muscle relaxation, guided imagery therapy, combined therapy, cognitive behavioral intervention, reflexology, self-administered acupressure, exercise, poetry appreciation, auricular acupressure, virtual reality relaxation, and reiki were each used frequently by fewer than 20% of nurses.

Is this study relevant to nursing practice outside Japan, such as in Canada?

It offers useful comparative insight and discussion points, but because the sample and health system are Japan-specific and self-reported, findings should not be assumed to directly generalize to Canadian palliative care settings without local assessment.

What kind of study design was used?

A nationwide, multicenter, cross-sectional online survey of registered nurses working in Japanese palliative care units.

Why didn't the researchers run statistical significance tests?

The abstract states the researchers chose to calculate descriptive statistics on implementation frequencies instead of performing statistical tests, consistent with the study's exploratory, practice-mapping purpose.

What does this study suggest for improving palliative care?

The authors suggest their findings 'offer insights for expanding palliative care support options,' implying a need to address the gap between commonly used comfort measures and rarely used specialized therapies.

Where was this study published and who wrote it?

It was published in Palliative Medicine Reports (2025) by Miharu Morikawa, Masamitsu Kobayashi, Kohei Kajiwara, Kimiko Nakano, Yusuke Kanno, Yoshinobu Matsuda, and Jun Kako (DOI: 10.1089/pmr.2024.0103).